As SDC of parotid gland has morphologic and molecular similarity to breast cancer, it is recommended that apart from regular histopathological examination, additional immunohistochemical staining including HER-2 neu, Ki-67, p16, p53, estrogen receptors (ER), progesterone receptors (PR), epithelial membrane antigen (EMA), and carcinoembryonic antigen (CEA) should be performed, as proposed by many studies [25, 26]. The gene discussed is ESR1; the disease is breast carcinoma.