NLRP3 and cryopyrin-associated periodic syndrome: For example, gain‐of‐function mutations in NLRP3 are associated with a group of heritable monogenic syndromes known as cryopyrin‐associated periodic syndromes (CAPS), characterized by excessive production of IL‐1β from APCs with recurrent fevers, skin rashes, joint and ocular inflammation, and amyloidosis in patients 34.