NLRP3 and gout: Exogenous signals inducing NLRP3 assembly include microbial, fungal, viral, and parasitic products such as toxins and glycans and environmental polluters such as silica and asbestos 3, 37, 38, 39 and disease‐associated accumulation of altered protein complexes, such as cholesterol crystals in atherosclerosis, amyloid β in Alzheimer disease and monosodium urate in gout 3, 5, 29.