Thus, NLRP3 appears to be a major sensor for cell metabolic activity and stress, and this is underscored by the recent observations that dysregulation of the NLRP3 inflammasome contributes also to metabolic diseases and pathologies, such as gout, type 2 diabetes (T2D), nonalcoholic fatty liver disease, obesity, and cancer (reviewed in 34). The gene discussed is NLRP3; the disease is metabolic dysfunction-associated steatotic liver disease.