NLRP3 and obesity due to melanocortin 4 receptor deficiency: Thus, NLRP3 appears to be a major sensor for cell metabolic activity and stress, and this is underscored by the recent observations that dysregulation of the NLRP3 inflammasome contributes also to metabolic diseases and pathologies, such as gout, type 2 diabetes (T2D), nonalcoholic fatty liver disease, obesity, and cancer (reviewed in 34).