Chang et al. have recently found that accumulated amyloid deposits, tau protein hyperphosphorylation and tau intracellular redistribution emerged rapidly in DS-iPSCs-derived neurons within 45 days but not in normal ESCs-derived neurons, suggesting DS-iPSC-derived neural cells can serve as an ideal cellular model of DS and AD and have potential for high-throughput screening of therapeutic candidates [76]. Here, MAPT is linked to amyloidosis.