In particular, a positive trend between TLR2 del/del genotype and an increasing risk for HCC (i.e CHC: 4.3%; CIR: 4.9%; HCC: 10.3%) was found; by contrast, the TLR2 del/del prevalence in NHL patients (0.9%) was similar to that found in BDs (1.3%). Here, TLR2 is linked to Diamond-Blackfan anemia.