Thus, considering that HCV is also a lymphotropic virus, our haplotype analysis pointed out that in the presence of a HCV chronic persistence, the TLR2 ins/ins-IL28B-C/C arrangement could increase the susceptibility to lymphoproliferative complications, including mixed cryoglobulinemia and B-cell NHL (p = 0.029, OR 1.77, Table 4). The gene discussed is TLR2; the disease is B-cell non-Hodgkin lymphoma.