MCL1 and rhabdomyosarcoma: As noted above, Ramírez-Peinado et al. [5] reported that 2-DG is toxic to a number of rhabdomyosarcoma cell lines when treated under normoxia which correlated with up-regulation of the pro-apoptotic BH3-only protein Noxa and consequent down-regulation of its anti-apoptotic protein target, Mcl-1.