TBX21 and experimental autoimmune encephalomyelitis: We used two models of inflammation, experimental autoimmune encephalomyelitis (EAE) and the Helicobacter hepaticus typhlocolitis model, to examine whether conversion of Th17 cells into Th1-like cells (defined by the expression of Tbet and IFN-γ, and absence of RORγt, IL-17A, and IL-17F) is necessary for immunopathology.