High SETD7 expression [95% confidence interval (CI), 2.026–4.607; p<0.001], AFP value of >200 ng/ml [95% CI, 1.004–1.956; p = 0.047], tumor size of >5cm [95% CI, 1.349–2.629; p<0.001], multiple tumors [95% CI, 1.085–2.225; p = 0.016], recurrence [95% CI, 1.277–2.495; p = 0.001], metastasis [95% CI, 1.522–3.074; p<0.001] and poor tumor differentiation [95% CI, 1.005–1.947; p = 0.047] are associated with reduced OS. This evidence concerns the gene SETD7 and neoplasm.