To further investigate the clinical significance of SETD7 expression in the development and progression of HCC, primary HCC samples were divided into two groups, low expression of SETD7 (IHC score: 0–2, n = 74) and high expression of SETD7 (IHC score: 3–6, n = 151). This evidence concerns the gene SETD7 and hepatocellular carcinoma.