On the other hand, PRRSV could inhibit IFN-mediated JAK-STAT signaling pathways to interrupt ISG transcription; for example, ISG15, ISG56, CCL2, MX1, OAS2, and RNaseL of PAMs were significantly downregulated after infection with the PRRSV strain VR2385 [48]. The gene discussed is ISG15; the disease is infection.