Primary mutations in LMNA are well-documented causes of inherited diseases collectively called the “laminopathies” that include isolated cardiac disease with arrhythmia and DCM [10,27,28]; skeletal myopathies: Emery-Dreifuss muscular dystrophy and limb-girdle muscular dystrophy; premature aging syndromes as Hutchinson-Gilford progeria syndrome (HGPS); and lipodystrophies. This evidence concerns the gene LMNA and cardiac arrhythmia.