To address this issue specifically we reconstituted RAG2-/-γc-/- mice with splenocytes (SplC) from either WT or CatB-/- mice (RAG2-/-γc-/- + WT or RAG2-/-γc-/- + CatB-/- SplC, respectively) and measured FP thickness after infection with L. major. RAG2-/-γc-/- + CatB-/- SplC showed less FP swelling compared with mice reconstituted with WT cells at days 21–35 p.i. (Fig 8A). This evidence concerns the gene RAG2 and infection.