We initially reconstituted RAG2-/-γc-/- mice with splenocytes from either WT or CatB-/- and observed FP thickness after infection with L. major. RAG2-/-γc-/- mice reconstituted with CatB-/- splenocytes developed significantly smaller lesions throughout the course of infection compared with mice reconstituted with WT cells. The gene discussed is TYRP1; the disease is infection.