TYRP1 and leishmaniasis: We also observed a lower IL-10 transcript expression in CatB-/- mice around day 21–28 p.i. (Fig 6C) Since the IFNγ-inducible Nitric Oxide Synthase (iNOS) axis is well recognized as an effector mechanism in leishmaniasis we also monitored the levels of iNOS transcripts in dLNs and FPs of infected mice.