In recent years there has been escalating evidence which highlights the significance of vitamin D role in the response of immune system against mycobacterium tuberculosis which is an important predictor in the possible outcomes of tuberculosis.4 There is up regulation of expression of vitamin D receptor and 25-hydroxyvitamin D-1α-hydroxylase after the activation of a macrophage or monocyte through stimulation of its toll-like receptor 2/1 (TLR2/1) by Mycobacteriumtuberculosis or otherinfectious agents. Here, TLR2 is linked to tuberculosis.