Deranged renal profile in a patient with cirrhosis and ascites in the absence of alternative causes of renal impairment and failure to respond to trial of intravenous albumin is sufficient to diagnose HRS.2 It is classified as type 1 and 2 based on value of serum creatinine and time it has taken to worsen.3 Median survival for patients with HRS is three months. The gene discussed is ALB; the disease is Ascites.