Results showed that the total protein levels of FAK and Src were the same between ND and HD (Fig. 1A), the relative levels of activating froms p-FAK-Tyr407 and p-Src-Tyr416 were significantly up-regulated by ~3-fold (Fig. 1B,C), while the deactivating form p-Src-Tyr529 was down-regulated by ~50% (Fig. 1C) in HD, indicating the activation of both FAK and Src in HD. This evidence concerns the gene PTK2 and Huntington disease.