CES1 and metabolic dysfunction-associated steatohepatitis: Notably, the present study showed that although circulating cytokines were not comprehensively increased in Pemt−/− mice when compared with WT mice, TGH deficiency reduced circulating concentrations of several cytokines in Pemt−/− mice after 10 weeks HFD, which may have also contributed to the amelioration of NASH in the Tgh−/−/Pemt−/− mice.