We also analyzed autophagic cell death 24 hours after stroke, and found that the LC3-II/LC3-I ratio in mice treated with tPA was substantially reduced by >30% by rADAMTS 13, indicating that rADAMTS 13 markedly inhibits tPA-induced conversion from LC3-I to LC3-II (Fig. 3E). The gene discussed is PLAT; the disease is stroke disorder.