Very recently, we have shown that circulating ZAG levels are lower in patients with newly diagnosed T2DM than in healthy subjects and are positively correlated with ADI, and inversely with body mass index (BMI), waist-to-hip ratio (WHR), and homeostasis model assessment of insulin resistance (HOMA-IR), further suggesting that ZAG may be an adipokine associated with IR17. The gene discussed is AZGP1; the disease is Insulin resistance.