FUS and amyotrophic lateral sclerosis: ALS appears mostly sporadic (sALS), but can be inherited (fALS) due to mutations in e.g. superoxide dismutase 1 (SOD1), TAR DNA-binding protein 43 (TDP-43), Fused in Sarcoma (FUS) and C9ORF72 (chromosome 9 open reading frame 72)1, 2.