For example, just a partial inhibition in Megalin recycling may account for the large absorptive effects observed in patients with recycling machinery mutations, for example, Lowe syndrome (PI4,5P2 5-phosphatase OCRL) and Dent's disease (CLC-5) (refs. 45, 48, 49, 50). Here, CLCN5 is linked to Dent disease.