While in MB tumors nearly all DDX3X mutations are nonsynonymous single nucleotide variants that are capable of expressing stable DDX3X proteins harboring single amino acid substitutions (Fig. 1a), other tumor types such as various blood cancers often display other DNA changes leading to frameshifts, spliced variants, and chromosome rearrangements between the DDX3X and other loci2, 3, 5, 6. Here, DDX3X is linked to hematopoietic and lymphoid system neoplasm.