We also used a publically available database (http://www.proteinatlas.org/)45 to investigate the expression levels and cellular distribution of DDX3X in other tumor types and observed a similar high levels and punctate distribution in a wide range of human cancers including glioma, melanoma and breast carcinoma tumors compared to normal tissues (Supplementary Figure S1b). This evidence concerns the gene DDX3X and central nervous system cancer.