Moreover, the discovery that BRCA1-KO fibroblasts change their fate completely and turn into colon cancer cells and pancreatic cancer cells, when exposed to serum derived from patients affected by metastatic colon and pancreatic cancer, strengthen the belief of the authors, that similarity doesn’t imply sameness and therefore metastatic cells might not necessarily be only cells detaching from primary tumors. Here, BRCA1 is linked to colonic neoplasm.