In AML patients, lncRNA IRAIN [176], which is transcribed from the IGF1R imprinted locus, is down-regulated in patients with high-risk AML, while urothelial carcinoma-associated 1 (UCA1) lncRNA is specifically up-regulated in AML [177], although its role in the pathogenesis is unclear. This evidence concerns the gene UCA1 and acute myeloid leukemia.