CD8A and neoplasm: Intracellular cytokine staining following stimulation with tumor cells showed that when compared to SD, the KD significantly increases the ability of tumor-reactive CD8+ T cells to produce interferon gamma (IFNγ), tumor necrosis factor (TNF), and interleukin 2 (IL-2) when stimulated with GL261-Luc2 cells (Fig. 4a).