Further, we propose that mouse models of CRC initiation and progression, such as the Cre-Lox model of APC inactivation [74] be used to ascertain the in vivo chemopreventive efficacy of cotreatment with HDACis and ICG-001, ICG-427, and/or IQ-1, compared with these agents used in isolation. This evidence concerns the gene APC and colorectal carcinoma.