CTNNB1 and colorectal carcinoma: Thus, we demonstrated that Dkk-1 and sFRP2, Wnt-signaling antagonists, which interfere with Wnt ligand-receptor interactions at the cell membrane [45-55], inhibit the upregulation of active beta-catenin and the hyperactivation of Wnt transcriptional activity by the HDACis NaB, TSA, SAHA, and MS-275 in CRC cells [2].