In summary, CBP- and p300-mediated Wnt signaling likely influences the (1) differential response of CRC cell lines to HDACis, (2) maintenance of low- and high-Wnt fractions within single CRC cell lines, which may be representative of in vivo tumor heterogeneity, and (3) progression of colonic neoplasia from normal cells to metastatic carcinoma. Here, EP300 is linked to neoplasm.