NALCN and Cognitive impairment: Furthermore, our results identify key cellular responses that are impaired in the absence of NALCN, and may have therapeutic value as human mutations in NALCN lead to severe motor and cognitive deficits (Chong et al., 2015; Aoyagi et al., 2015; Al-Sayed et al., 2013; Köroğlu et al., 2013; Fukai et al., 2016).