Reduced expression of H19 was observed in clinically untreated chronic myeloproliferative disorders, including chronic myeloid leukemia (CML), polycythemia vera (PV), essential thrombocythemia (ET), primary myelofibrosis (PMF) and chronic myelomonocytic leukemia (CMML), as well as in AML [53, 54]. This evidence concerns the gene H19 and essential thrombocythemia.