CDKN2B-AS1 and leukemia: In fact, ANRIL could be involved in cis recruitment of Polycomb Repressive Complex 1 (PRC1) and 2 (PRC2) for the epigenetic silencing of p14, p15, and p16, with subsequent induction of cell cycle perturbations, differentiation block, and apoptosis arrest in blood cells, leading to leukemia.