NOTCH1 and acute lymphoblastic leukemia: Recently, Trimarchi et al. [72] have shown that a specific NOTCH1-regulated lncRNA, LUNAR1 (LeUkemia-induced Non-coding Activator RNA-1), is upregulated in NOTCH1 mutated T-ALL and is essential for efficient T-ALL growth in vitro and in vivo due to its ability to enhance the expression of its neighboring coding gene on chromosome 15, IGF1R, thus sustaining the IGF1 signaling.