Recently, Trimarchi et al. [72] have shown that a specific NOTCH1-regulated lncRNA, LUNAR1 (LeUkemia-induced Non-coding Activator RNA-1), is upregulated in NOTCH1 mutated T-ALL and is essential for efficient T-ALL growth in vitro and in vivo due to its ability to enhance the expression of its neighboring coding gene on chromosome 15, IGF1R, thus sustaining the IGF1 signaling. This evidence concerns the gene LUNAR1 and acute lymphoblastic leukemia.