Taken together, our data indicate that both miR-203 and miR-542-3p contribute to entinostat-mediated reduction of Survivin; and upregulation of the two miRNAs is necessary and sufficient for entinostat potentiation of paclitaxel-induced growth inhibition and apoptosis in NSCLC cells. This evidence concerns the gene BIRC5 and non-small cell lung carcinoma.