AKT1 and Sepsis: Recently, autophagy has also been involved in sepsis-induced muscle wasting [5] Protein kinase B (Akt)/ Forkhead box protein O (FoxO) and nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) are cellular pathways and transcription factors that are clearly involved in muscle atrophy in sepsis and activate the ubiquitin-proteasome system and autophagy [6, 7].