CM obtained from CAFs treated with octreotide, another somatostatin analog presenting a high binding-affinity for sst2 but unable to activate sst1, keep their stimulatory effect on pancreatic cancer cell survival (Supplementary Figure 3A and 3B), suggesting that sst1 but not sst2 mediates SOM230 action. This evidence concerns the gene SSTR2 and familial pancreatic carcinoma.