In the present study, we analyzed 373 patients with BCP-ALL without hyperdiploid karyotype and recurrent fusions, such as ETV6-RUNX1, E2A-PBX1, MLL-related fusions and BCR-ABL, because we did not have enough data for gene expression profiling, which is mandatory for the diagnosis of Ph-like ALL. The gene discussed is PBX1; the disease is acute lymphoblastic leukemia.