IL1B and Insulin resistance: Since insulin resistance and metabolic dysfunction are closely related to inflammatory status, we checked proinflammatory cytokine levels in plasma, and found plasma levels of IL-1β and IL-6 were reduced by LFE treatment (300 mg/kg) (by 98.2 ± 12.0% and 35.3 ± 8.96%, respectively) (Fig 5D).