To evaluate the combination effect of p110β/δ and JNK inhibition on tumor growth Balb/C nude mice bearing U-87 MG glioblastoma xenograft were treated with vehicle, TGX-221 (40 mg/kg) and CAL-101 (20 mg/kg) alone, or in combination with SP600125 (40 mg/kg). This evidence concerns the gene MAPK8 and neoplasm.