Inhibition of p110β or p110δ, but not p110α, exerted synergism with JNK on impeding glioblastoma cell proliferation and migration through decreasing Akt, focal adhesion kinase (FAK) and zyxin phosphorylation, resulting in the blockade of lamellipodia and membrane ruffles formation. Here, AKT1 is linked to glioblastoma.