TOP2A and cervical cancer: Therefore, molecules related to cell cycle regulation [p53, p21, Bcl-2-associated X protein, p27, retinoblastoma protein, p16 INK4a, minichromosome maintenance protein 2 (MCM2), topoisomerases type IIa (TOP2A), cyclin D1, cyclin A, and cyclin E] and cell proliferation (proliferating cell nuclear antigen, Ki-67, and c-myc) are used as biomarkers for cervical cancer diagnosis [6].