The module comprises 13 genes (FBXO11, HECTD1, HIST1H2BJ, HIST2H2BE, NOC2L, RNF168, RNF20, SET, SUMO1, SUMO2, UBC, YWHAQ, ZFP91) with 13 PTM-associated mutations distributed across 13 lung adenocarcinoma (LUAD) patients or one gene mutation per patient (Fig. 4c). The gene discussed is RNF20; the disease is lung adenocarcinoma.