LIPA and glaucoma: Two variants (p.A10S in TRMU and.G185S in ACADS) also appear in HGMD [13], and are flagged as “clinically associated” in dbSNP, p.R76K in MYOC was believed to contribute to glaucoma in a di-genic inheritance [25] and p.G5R in LIPA was shown in a functional assay to cause reduced enzymatic activity [26].