KMT2E and Hepatic fibrosis: We then considered whether intrahepatic NKp44+ NK cells were able to interfere with hepatic stellate cells (HSCs), which are considered the main contributors to liver fibrosis.30 NKp44L expression was tested on the LX-2 human HSC cell line, which retains key features of primary HSCs.2,31 The failure of the LX-2 cells, unlike the Hep G2 hepatocellular cells, to express NKp44L (Supplementary Figure 4), suggests that NKp44+ NK cells do not target HSCs.