INS and psoriasis: Severe psoriasis has been suggested to be an independent cardiovascular risk factor.42 Our meta-analysis suggests that UA may be a potential target for preventing the incidence of metabolic disturbances (insulin sensitivity, rises in blood pressure, and cholesterol)39 or cardiovascular risk factors.35 On the contrary, it remains to be determined whether the relationship between UA and cardiovascular events is circumstantial or causal in patients with psoriasis from Western Europe.