A previous study proposed decline in neurocognitive functions to be associated with low quality of life and a reduced adrenocorticotropic hormone (ACTH) response to corticotrophin-releasing hormone.7 In addition, chronic WS reduced brain volumes of the anterior cingulate cortex, dorsolateral prefrontal cortex, caudate, and putamen.8 Few reports have documented that stress might alter the immunity status. This evidence concerns the gene POMC and Werner syndrome.