HMGCR and cancer: Antitumor effects by statin have been demonstrated in various experimental studies.15–21 Cancer cells are fast-growing cells that are characterized by increased glycolysis and lipid biosynthesis to meet the metabolic needs of the cells and to provide cholesterol for cell membrane stability and growth, which can ultimately lead to angiogenesis.22 The main effect of statins on cancer cells is the inhibition of cholesterol synthesis through the inhibition of HMG-CoA reductase, the rate-limiting enzyme in the cholesterol-synthesis pathway,23 which may lead to increased cancer cell apoptosis.24