VEGFA has been illustrated to promote the differentiation, proliferation, and migration of microvascular endothelial cells by binding to their receptors, thus facilitating microvessel formation and development.43 Moreover, VEGF could not only promote the progress of blood vessel recanalization and the establishment of collateral circulation, but also enhance the dependent vasodilatation of the endothelial cells all of which are closely linked with CHD. This evidence concerns the gene VEGFA and coronary artery disorder.