When compared with AACC carriers, carriers of VEGFA (rs1570360 AA) and VEGFR2 (rs2305948 TT) were more likely to develop CHD, while carriers of AGCC, AGCT, GGCC, GGCT, and GGTT appeared to be less vulnerable to CHD (all P < 0.05). This evidence concerns the gene VEGFA and coronary artery disorder.