In summary, the present study indicated that polymorphisms in VEGFA [rs3025039 (C > T), rs1570360 (A > G), and rs699947 (C > A)] and VEGFR2 [rs2305948 (C > T), rs1870377 (T > A), and rs7667298 (A > G)] were notably correlated with altered CHD susceptibility in the Han Chinese population, when potential effects of living habits (e.g., smoking and alcohol intake) or complications (e.g., hypertension and diabetes) were removed. Here, VEGFA is linked to diabetes mellitus.