Therefore, in the present study, it was hypothesised that the HGF/Met axis drives radioresistance in breast cancer patients, and it was aimed to determine MET and HGF gene copy number, Met/HGF expression, and Met phosphorylation in breast tumours of patients randomised to receive either chemo- or radiotherapy, in order to study correlations with clinicopathological parameters and response to radiotherapy. This evidence concerns the gene MET and breast cancer.