In multivariable Cox regression analysis, including both cohorts adjusting for lymph node involvement, tumour size, ER and HER2 status, and stratified for cohort, MET amplification was associated with a significantly increased rate of distant recurrence (HR = 2.73; 95% CI: 1.36-5.5, p=0.005). This evidence concerns the gene ERBB2 and neoplasm.