Biallelic, public APC inactivations were also observed for two MSI-H gastric adenomas, in that each genome contained one nonsense mutation and one out-of-frame indel involving APC (e.g., p.R215X/p.K1452fs for MSI-H1 and p.R1450X/p.Y158fs for MSI-H2, respectively). Here, APC is linked to gastric adenoma.