SOD1 and amyotrophic lateral sclerosis: CuII(atsm) releases coordinated copper in elevated reductive states [e.g. hypoxic tissues, electron transport chain (ETC) compromised cells] [8, 53, 54] and corrected superoxide dismutase (SOD) (cuproenzyme) levels in copper deficient spinal cords of ALS mice [52, 54].