IFNB1 and Sandhoff disease: However, levels of Ifnb1 were only significantly up-regulated in cerebral hemispheres from nGD mice, and to a small extent in Krabbe mice; no significant elevation was detected in either NPC1 or in Sandhoff disease (Table 2), suggesting that the antiviral response is elevated specifically in diseases in which simple glycosphingolipids are elevated.