INS and polycystic ovary syndrome: However, the PRT group experienced no change in HOMA-2, several key endocrine markers (i.e. free androgen index [p = 0.18], testosterone [p = 0.91], SHBG [p = 0.246]) or other key haemotological markers associated with PCOS (i.e. CRP, fasting insulin) versus the control group (Table 2).