DNMT1 and breast carcinoma: In our present study, BIX diminished the interactions of EHMT2 with DNMT1 and the addition of 5-Aza-Cd synergistically reactivated Beclin-1 in breast cancer cells, which could be partially accounted for by the reversal of an ‘epigenetic double lock’ for gene silencing by both DNA and histone methylation.