RUNX3 and cancer: Cancers with these elevated expression levels exhibit silencing of critical tumor suppressor genes or epithelial-to-mesenchymal transition (EMT)-related genes, such as E-cadherin [17], p21 [18], p14ARF [19], human mutL homolog 1 (hMLH1) [20, 21], runt-related transcription factor 3 (RUNX3) [22, 23], desmocollin 3 (DSC3), mammary serine protease inhibitor (MASPIN) [24, 25], and E2F1 [26–28].