Also, gremlin, once released by tumor cells, stimulates neovascular and pro-inflammatory responses in a BMP-independent manner [14] due to its capacity to bind and activate vascular endothelial growth factor (VEGF) receptor-2 (VEGFR2), the main transducer of VEGF-mediated angiogenic signals [15–17], and to bind heparan-sulphate proteoglycans (HSPGs) [18, 19] on endothelial cells (ECs). The gene discussed is GREM1; the disease is neoplasm.