DLC1 and cancer: Hypermethylation of the CpG-rich promoter region of the DLC1 variant 2 transcript, which is both the most abundant one and the one that has been studied in greatest detail, has been found in a number of cancers [12–13], but less is known about methylation of the DLC2 and DLC3 promoters (DLC promoter sequences are shown in Figure S2).