In liver CSCs, Cao et al. reported that osteopontin promotes a cancer stem-like phenotype in HCC cells through an integrin- NF-κB- HIF1α pathway and up-regulates the expression of HIF1α downstream gene BMI1, which is essential for mediating the maintenance of the stem-like phenotypes33. The gene discussed is NFKB1; the disease is hepatocellular carcinoma.