In the discovery cohort, only rs13091182 within ZBTB38 showed nominalevidence of a 3-way interaction involving time outdoors (uncorrectedP = 0.028; correctedP > 0.05; Fig. 3f).Surprisingly, the risk allele of rs13091182 was associated with slowerprogression towards myopia (or less hyperopia) in general and with fasterprogression towards myopia in children who spent more time outdoors,suggesting a potentially false-positive result. The gene discussed is ZBTB38; the disease is myopia.