However, in our E-cadherin reexpression experiment, only E-cadherin (ORF) region without 5′-UTR (contains transcription factor binding sites) and 3′-UTR (contains classical miRNA binding sites) has been cloned into expression vector, what caused that metastatic cancer cells fail to increase the protein level of E-cadherin with highly transcribed E-cadherin (ORF) mRNA level. This evidence concerns the gene CDH1 and metastatic malignant neoplasm.